
Autotaxin inhibitor compound 1
CAS No. 1619971-30-0
Autotaxin inhibitor compound 1( Autotaxin-IN-1 )
Catalog No. M12375 CAS No. 1619971-30-0
Autotaxin inhibitor compound 1 (Autotaxin-IN-1) is a potent, selective, orally bioavailable inhibitor of autotaxin with IC50 of 2.2 nM in ex vivo human whole blood assay.
Purity : >98% (HPLC)






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50MG | 1962 | Get Quote |
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100MG | 2520 | Get Quote |
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Biological Information
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Product NameAutotaxin inhibitor compound 1
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NoteResearch use only, not for human use.
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Brief DescriptionAutotaxin inhibitor compound 1 (Autotaxin-IN-1) is a potent, selective, orally bioavailable inhibitor of autotaxin with IC50 of 2.2 nM in ex vivo human whole blood assay.
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DescriptionAutotaxin inhibitor compound 1 (Autotaxin-IN-1) is a potent, selective, orally bioavailable inhibitor of autotaxin with IC50 of 2.2 nM in ex vivo human whole blood assay, does not inhibit related proteins ENPP1 and ENPP7; demonstrates significant anti-inflammatory and analgesic effects in the carrageenan-induced paw inflammation and acetic acid-induced visceral pain tests, respectively; also significantly inhibits disease activity score in the dextran sodium sulfate-induced model of inflammatory bowel disease (IBD) and in autoimmune encephalomyelitis model of multiple sclerosis (MS).
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In Vitro——
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In VivoAutotaxin-IN-1 (i.v.; 1.0mg/kg) has T1/2 of 1.14 hours.Autotaxin-IN-1 (p.o.; 10 mg/kg) has Cmax of 660 nM and AUC of 3440 nM?h. Animal Model:Normal ratDosage:1.0 mg/kg, 10 mg/kg (Pharmacokinetic Study) Administration:I.v. (1.0 mg/kg); p.o. (10 mg/kg)Result:Has T1/2 of 1.14 hours (i.v.; 1.0mg/kg).Has Cmax of 660 nM and AUC of 3440 nM?h (p.o.; 10 mg/kg).
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SynonymsAutotaxin-IN-1
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PathwayWnt/Notch/Hedgehog
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TargetAutotaxin
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RecptorAutotaxin
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Research Area——
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Indication——
Chemical Information
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CAS Number1619971-30-0
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Formula Weight405.462
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Molecular FormulaC21H23N7O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(N1CC2=NC(NC3CC4=C(C=CC=C4)C3)=NC=C2C1)COCCC5=CNN=N5
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Chemical Name2-(2-(1H-1,2,3-triazol-4-yl)ethoxy)-1-(2-((2,3-dihydro-1H-inden-2-yl)amino)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)ethan-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Thirunavukkarasu K, et al. J Pharmacol Exp Ther. 2016 Oct;359(1):207-14.
2. Jones SB, et al. ACS Med Chem Lett. 2016 Aug 2;7(9):857-61.
molnova catalog



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