Autotaxin inhibitor compound 1 ( Autotaxin-IN-1 )

Catalog No. M12375 CAS No. 1619971-30-0

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Datasheet

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Product Name

Autotaxin inhibitor compound 1
Note

Research use only, not for human use.
Brief Description

Autotaxin inhibitor compound 1 (Autotaxin-IN-1) is a potent, selective, orally bioavailable inhibitor of autotaxin with IC50 of 2.2 nM in ex vivo human whole blood assay.
Description

Autotaxin inhibitor compound 1 (Autotaxin-IN-1) is a potent, selective, orally bioavailable inhibitor of autotaxin with IC50 of 2.2 nM in ex vivo human whole blood assay, does not inhibit related proteins ENPP1 and ENPP7; demonstrates significant anti-inflammatory and analgesic effects in the carrageenan-induced paw inflammation and acetic acid-induced visceral pain tests, respectively; also significantly inhibits disease activity score in the dextran sodium sulfate-induced model of inflammatory bowel disease (IBD) and in autoimmune encephalomyelitis model of multiple sclerosis (MS).
Synonyms

Autotaxin-IN-1
Pathway

Wnt/Notch/Hedgehog
Target

Autotaxin
Recptor

Autotaxin
Research Area

——
Indication

——

CAS Number

1619971-30-0
Formula Weight

405.46
Molecular Formula

C21H23N7O2
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(N1CC2=NC(NC3CC4=C(C=CC=C4)C3)=NC=C2C1)COCCC5=CNN=N5
Chemical Name

2-(2-(1H-1,2,3-triazol-4-yl)ethoxy)-1-(2-((2,3-dihydro-1H-inden-2-yl)amino)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)ethan-1-one

1. Thirunavukkarasu K, et al. J Pharmacol Exp Ther. 2016 Oct;359(1):207-14.
2. Jones SB, et al. ACS Med Chem Lett. 2016 Aug 2;7(9):857-61.

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